Blood Blockade Battlefront

Three years ago, a gateway between Earth and the Beyond opened over the city of New York. In one terrible night, New York was destroyed and rebuilt, trapping New Yorkers and extra-dimensional creatures alike in an unassailable island, a world all its own hidden in the mist of its physics-defying waterfalls.
New York has been rechristened Jerusalem's Lot, a paranormal melting pot where magic and madness dwell alongside the mundane, where every form of human vermin gathers to exploit otherworldly assets for earthly profit. Now someone is threatening to breach the controlled flow of unharmful, average humans and items in and (much more rarely) out of the city and thereby release Jerusalem's Lot's deluge of horrors on The Outside. The mysterious super-agents of Libra fight the impossible to prevent the unthinkable.
(Source: Dark Horse)

Note: Includes the one-shot "Kekkai Sensen: Mafuugai Kessha".