Natsume Kiroemon, the protagonist, was the 45th leader of the Natsume family, and inherit the "Kiryuu no Mimi ", a tool which gave its bearer easy access to wealth and women. As a result of his father's death, he left the Italian monastery where he'd been training and rightfully took the name "Natsume Kiroemon" as well as the power of the Kiryuu no Mimi. Upon his return to Japan, he fell fatally in love with Kanako, one of the members of the rival Mina family. However, the evil hand of the Mina family attacked Natsume constantly and abducted Kanako. Now Natsume has unlocked the seal, making the Kiryuu's power surge, and he's striking back at the Mina family.

The story take place in the Kabukicho district of Shinjuku. A man from the north, appeared in the area. We do not know who he is. But soon it will be mayhem. It will then attract the attention of a young inspector. Source: MAL

The drug 'Nightmare' gives a drastic impact, changing a human physical to a gigantic creature. Then a man appeared to stand up against these creatures for the sake of prosperity and to prevent misfortunes of mankind.