This is a sequel to Saijou no Meii. Dr. Mogami currently has two major problems on his mind. The first is that the young, genius surgeon from the previous series, Saijou Mikoto, has fallen terribly ill. The second is his delinquent, shut-in son, Yoshiaki. He just knows that Yoshiaki has a lot of potential, but he's failed at raising him. Yoshiaki is nothing but a lazy, arrogant, spoiled brat. After Dr. Mogami kicks him out of the house, in hopes that it will do him good, Yoshiaki crashes with his childhood friend Date Masamune. Date is also something of a punk, but, to Yoshiaki's surprise, he's decided to try to study to become a doctor. The combined efforts of Date and his father slowly nudge him back on track. After a near-tragic occurrence, Yoshiaki even begins to think that maybe he should become a doctor, too!

There's English bread, German bread and French bread, but Japan's bread, Ja-pan, does not exist... In that case, there's no choice but to create it! This was story of the manga and anime named Yakitate!! Japan, a story that a young baker in real life named Daisaku Hiromi admires and aspires to do the same! But alas, to actually create Ja-pan is not simple as Daisaku believed, leaving him bitter at the reality itself. But Daisaku's pain-staking reality begins to change as a mysterious beauty approaches the front door of his bakery. This is the story of a "real-life" serious boy who aims to bake what appears to be fiction into reality, and thus presented to the world proudly.

A young boy named Mikoto Saijou was saved as a child by a skilled surgeon. After recuperating, the boy vows to dedicate his life to becoming the world's greatest pediatrician.