Yaji and Kita are two men who live in Edo. They are deeply in love. Yaji is married to a woman, while Kita is an actor addicted to various drugs. One day, they receive an advertisement for the Grand Shrine at Ise, and decide to set out on a pilgrimage there, hoping to cure Kita of his drug addiction. They set out on a modern motorcycle but are forced to turn back and walk the Tokaido road to Ise, encountering various characters and obstacles along the way.

Hioki Nanao is a high school student with a constitution that attracts youkai. The adoptive father of Nansei is a vampire specializing in youkai, and Hioki is a writer who usually works as a writer. Youkai-related troubles never cease to exist around the youkai's bait Nansei and the hunter's main account.